3-Hydroxy-2-phenyl-4(1H)-quinolinones as Promising Biologically Active Compounds

Author(s): P. Hradil, J. Hlavac, M. Soural, M. Hajduch, M. Kolar, R. Vecerova

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 9 , Issue 6 , 2009

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2-Phenyl-3-hydroxy-4(1H)-quinolinones can be considered as aza-analogues of flavones, compounds which are known for the wide-range of their biological activity. These quinolinones were studied as inhibitors of topoisomerase, gyrase and IMPDH. They were tested for anticancer activity in-vitro and were also shown to possess immunosuppressive properties. This review is the first summarizing the synthesis and activity of the mentioned quinolinones.

Keywords: Quinolinones, anticancer activity, antibacterial activity, inhibition

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Article Details

Year: 2009
Page: [696 - 702]
Pages: 7
DOI: 10.2174/138955709788452720
Price: $65

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