Recent Advances in Synthesis of PAR Ligands as Therapeutic Strategy for Inflammatory Diseases

Author(s): B. Severino, V. Santagada, E. Perissutti, F. Fiorino, F. Frecentese, F. De Angelis, A. Esposito, G. Caliendo

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 9 , Issue 6 , 2009

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Abstract:

Several studies have been published on discovering involvement of PARs receptors in a number of disease states, including cancer and inflammation of the cardiovascular, respiratory, musculoskeletal, gastrointestinal and nervous systems. This mini-review will focus on recent advances in the synthesis of PAR ligands highlighting their therapeutic potential in the treatment of various inflammatory diseases.

Keywords: Protease activated receptors, inflammation, agonist, antagonist, peptide-mimetic, small-molecule

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Article Details

VOLUME: 9
ISSUE: 6
Year: 2009
Page: [653 - 663]
Pages: 11
DOI: 10.2174/138955709788452711
Price: $65

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