Title: Recent Advances in Synthesis of PAR Ligands as Therapeutic Strategy for Inflammatory Diseases
VOLUME: 9 ISSUE: 6
Author(s):B. Severino, V. Santagada, E. Perissutti, F. Fiorino, F. Frecentese, F. De Angelis, A. Esposito and G. Caliendo
Affiliation:Department of Pharmaceutical and Toxicological Chemistry, University of Naples “Federico II”, via D. Montesano 49, -80131 Naples, Italy.
Keywords:Protease activated receptors, inflammation, agonist, antagonist, peptide-mimetic, small-molecule
Abstract: Several studies have been published on discovering involvement of PARs receptors in a number of disease states, including cancer and inflammation of the cardiovascular, respiratory, musculoskeletal, gastrointestinal and nervous systems. This mini-review will focus on recent advances in the synthesis of PAR ligands highlighting their therapeutic potential in the treatment of various inflammatory diseases.
