Ceric Ammonium Nitrate: An Efficient Catalyst for One-Pot Synthesis of 2,2,4-Trimethyl-1,2-dihydroquinolines

Author(s): Shylaprasad Durgadas, Vijay K. Chatare, Khagga Mukkanti, Sarbani Pal.

Journal Name: Letters in Organic Chemistry

Volume 7 , Issue 4 , 2010

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Ceric ammonium nitrate (CAN) catalyzed the one-pot synthesis of 2,2,4-trimethyl-1,2-dihydroquinoline derivatives from substituted anilines and acetone via a modified Skraup reaction. The methodology was used to synthesize a novel dihydroquinoline-based compound derived from an anti-inflammatory agent nimesulide.

Keywords: CAN, catalysis, aniline, dihydroquinoline

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Article Details

Year: 2010
Page: [306 - 310]
Pages: 5
DOI: 10.2174/157017810791130586
Price: $65

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