Abstract
This review discusses the most active natural and synthetic compounds demonstrating the antimycobacterial activity at minimum inhibiting concentrations (MIC) of 5 μg/ml or less. For better insight into the “structure-activity” relationships, we occasionally considered compounds with high values of MIC. The review covers the period from 2001 to 2007. The data are grouped according to chemical structures, namely, nitrogen-, oxygen-, and sulfur-containing heterocyclic compounds, peptide, alkaloids, terpenoids, and others.
Keywords: Tuberculosis, multidrug-resistance tuberculosis, M. tuberculosis, antimycobacterial activity, antituberculosis activity, cytotoxicity, “structure-activity” relationships
Mini-Reviews in Organic Chemistry
Title: Natural and Synthetic Compounds with an Antimycobacterial Activity
Volume: 6 Issue: 2
Author(s): L. N. Rogoza, N. F. Salakhutdinov and G. A. Tolstikov
Affiliation:
Keywords: Tuberculosis, multidrug-resistance tuberculosis, M. tuberculosis, antimycobacterial activity, antituberculosis activity, cytotoxicity, “structure-activity” relationships
Abstract: This review discusses the most active natural and synthetic compounds demonstrating the antimycobacterial activity at minimum inhibiting concentrations (MIC) of 5 μg/ml or less. For better insight into the “structure-activity” relationships, we occasionally considered compounds with high values of MIC. The review covers the period from 2001 to 2007. The data are grouped according to chemical structures, namely, nitrogen-, oxygen-, and sulfur-containing heterocyclic compounds, peptide, alkaloids, terpenoids, and others.
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Rogoza N. L., Salakhutdinov F. N. and Tolstikov A. G., Natural and Synthetic Compounds with an Antimycobacterial Activity, Mini-Reviews in Organic Chemistry 2009; 6 (2) . https://dx.doi.org/10.2174/157019309788167657
DOI https://dx.doi.org/10.2174/157019309788167657 |
Print ISSN 1570-193X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6298 |
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