Natural and Synthetic Compounds with an Antimycobacterial Activity

Author(s): L. N. Rogoza, N. F. Salakhutdinov, G. A. Tolstikov.

Journal Name: Mini-Reviews in Organic Chemistry

Volume 6 , Issue 2 , 2009

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Abstract:

This review discusses the most active natural and synthetic compounds demonstrating the antimycobacterial activity at minimum inhibiting concentrations (MIC) of 5 μg/ml or less. For better insight into the “structure-activity” relationships, we occasionally considered compounds with high values of MIC. The review covers the period from 2001 to 2007. The data are grouped according to chemical structures, namely, nitrogen-, oxygen-, and sulfur-containing heterocyclic compounds, peptide, alkaloids, terpenoids, and others.

Keywords: Tuberculosis, multidrug-resistance tuberculosis, M. tuberculosis, antimycobacterial activity, antituberculosis activity, cytotoxicity, “structure-activity” relationships

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Article Details

VOLUME: 6
ISSUE: 2
Year: 2009
Page: [135 - 151]
Pages: 17
DOI: 10.2174/157019309788167657
Price: $65

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