Monitoring the Pharmacokinetics of Pyridinium Aldoximes in the Body

Author(s): H. Kalasz, J. Furesz, K. Tekes

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 9 , Issue 5 , 2009

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A huge number of organophosphate poisonings occurring in agriculture, and a constant threat of misapplication of organophosphates as warfare agents require antidotes that efficiently improve the health-condition of intoxicated subjects. Pyridinium aldoximes are medically used to reactivate the cholinesterase enzymes inhibited by organophosphates. This paper outlines pharmacokinetics, metabolic disposition and blood-brain-barrier penetration of pyridinium aldoximes into the human and animal body, and the methods of their pharmacological analysis.

Keywords: Pyridinium aldoximes, pralidoxime, K-27, K-48, K-203

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Article Details

Year: 2009
Page: [596 - 610]
Pages: 15
DOI: 10.2174/138955709788167565
Price: $65

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