EGF Receptor as a Drug Target in Arterial Hypertension

Author(s): J. Beltowski, E. Lowicka

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 9 , Issue 5 , 2009

Become EABM
Become Reviewer
Call for Editor


Drugs which inhibit epidermal growth factor receptor (EGFR) are used in the treatment of cancers. EGFR may contribute to the development of hypertension by regulating vascular tone and renal Na+ handling. Synthetic EGFR inhibitors reduce blood pressure in some experimental models of hypertension suggesting that this receptor is a novel target for antihypertensive therapy.

Keywords: Epidermal growth factor receptor, arterial hypertension, receptor transactivation, extracellular signal-regulated kinases, receptor tyrosine kinase inhibitors, leptin, metabolic syndrome

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2009
Page: [526 - 538]
Pages: 13
DOI: 10.2174/138955709788167619
Price: $65

Article Metrics

PDF: 12