Design and Synthesis of Thiazolidinedione Derivates as Selective PPARγ Modulators

Author(s): Xiangyang Sha, Huibin Zhang, Wenlong Huang, Jinpei Zhou, Yinghong Zhou

Journal Name: Letters in Drug Design & Discovery

Volume 6 , Issue 3 , 2009

Become EABM
Become Reviewer
Call for Editor


In this paper we reported the design, synthesis of a series of thiazolidinedione derivates. Their PPARγ activity in vitro was assessed using a reporter gene assay. In this series, it was demonstrated that compound 8f, 8g and 8h with substituted sulfonamino thiourea groups exhibited significant partial agonistic effects on PPARγ.

Keywords: Diabetes, PPAR, Synthesis, Thiazolidinedione, Sulfonamino thiourea

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2009
Published on: 01 March, 2012
Page: [224 - 227]
Pages: 4
DOI: 10.2174/157018009787847819
Price: $65

Article Metrics

PDF: 5