Renal & Ocular Targets for Therapy in Wegeners Granulomatosis

Author(s): Lavnish Joshi, Sally Hamour, Alan D. Salama, Charles D. Pusey, Sue Lightman, Simon R.J. Taylor

Journal Name: Inflammation & Allergy - Drug Targets (Discontinued)
(Formerly Current Drug Targets - Inflammation & Allergy)

Volume 8 , Issue 1 , 2009


Wegeners granulomatosis (WG) is a multisystem small-vessel vasculitis which is characterised by granulomatous inflammation. Respiratory tract involvement is most commonly seen, affecting up to 85% of patients, closely followed by the renal system in up to 75% of patients; ocular involvement in WG is estimated to occur in 50-60% of patients. The purpose of this review is to provide an overview of the renal and ocular manifestations of WG and discuss the rationale behind the therapeutic approach. In particular, we will focus on how understanding the disease processes in both of these organs has led to more targeted therapy. The mechanism of action of the various immunosuppressive medications in both systemic and ocular inflammation and the evidence available for their use will also be discussed.

Keywords: Wegener's granulomatosis, systemic vasculitis, ocular inflammation, immunosuppression

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Article Details

Year: 2009
Page: [70 - 79]
Pages: 10
DOI: 10.2174/187152809787582552

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