Title: Syntheses of NPTX-594 Analogs with Thiol-Containing Fluorophores to Develop a Probe for Analysis of Binding Mode Between Spider Toxins and Glutamate Receptors
VOLUME: 16 ISSUE: 3
Author(s):Takahiro Nishimaru, Yoshihiro Yamaguchi and Tateaki Wakamiya
Affiliation:Faculty of Science and Technology, Kinki University, Higashi-osaka, Osaka 577-8502, Japan.
Keywords:Spider toxin, NPTX-594, glutamate receptor (GluR), thiol-containing fluorophore, fluorescent label, cricket bioassay
Abstract: NPTX-594 is a neurotoxic acylpolyamine isolated from a Madagascar Joro spider and acts as a specific blocker of glutamate receptors (GluRs). The present study reports the creation of novel NPTX-594 analogs with thiol-containing fluorophores for use as visualization probes for the analysis of the binding mode between spider toxins and GluRs, together with the result of their cricket bioassay.