Syntheses of NPTX-594 Analogs with Thiol-Containing Fluorophores to Develop a Probe for Analysis of Binding Mode Between Spider Toxins and Glutamate Receptors

Title: Syntheses of NPTX-594 Analogs with Thiol-Containing Fluorophores to Develop a Probe for Analysis of Binding Mode Between Spider Toxins and Glutamate Receptors

VOLUME: 16 ISSUE: 3

Author(s):Takahiro Nishimaru, Yoshihiro Yamaguchi and Tateaki Wakamiya

Affiliation:Faculty of Science and Technology, Kinki University, Higashi-osaka, Osaka 577-8502, Japan.

Keywords:Spider toxin, NPTX-594, glutamate receptor (GluR), thiol-containing fluorophore, fluorescent label, cricket bioassay

Abstract: NPTX-594 is a neurotoxic acylpolyamine isolated from a Madagascar Joro spider and acts as a specific blocker of glutamate receptors (GluRs). The present study reports the creation of novel NPTX-594 analogs with thiol-containing fluorophores for use as visualization probes for the analysis of the binding mode between spider toxins and GluRs, together with the result of their cricket bioassay.

Cite this article as:

Takahiro Nishimaru, Yoshihiro Yamaguchi and Tateaki Wakamiya, “ Syntheses of NPTX-594 Analogs with Thiol-Containing Fluorophores to Develop a Probe for Analysis of Binding Mode Between Spider Toxins and Glutamate Receptors”, Protein & Peptide Letters (2009) 16: 285. https://doi.org/10.2174/092986609787601787

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