The Furan-2(5H)-ones: Recent Synthetic Methodologies and its Application in Total Synthesis of Natural Products

Author(s): Marcus Vinicius Nora De Souza

Journal Name: Mini-Reviews in Organic Chemistry

Volume 2 , Issue 2 , 2005

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In recent years, furan-2(5H)-ones have attracted considerable attention as synthetic target. This subunit is present in a large number of natural products, which display a wide range of biological activities, and is present in a number of drugs with diverse biological activities, such as antifungal, antibacterial and anti-inflammatory. It can also be used as synthetic intermediate. This review describes recent synthetic methodologies for preparation of furan-2(5H)-ones, as well as their application in the total synthesis of natural products with this subunit.

Keywords: furan-2(5h)-ones, biologic activity, natural products, synthetic methodologies

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Article Details

Year: 2005
Page: [139 - 145]
Pages: 7
DOI: 10.2174/1570193053544427
Price: $65

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PDF: 7