The Enantioselective Synthesis of Conformationally Constrained Cyclic β- Amino Acids

Author(s): Jason A. Miller, SonBinh T. Nguyen

Journal Name: Mini-Reviews in Organic Chemistry

Volume 2 , Issue 1 , 2005

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Abstract:

Enantiomerically pure and conformationally constrained cyclic β-amino acids have been the subject of a vast amount of research across the chemical, biological, and medicinal disciplines. These valuable molecules are synthetic precursors for a wide variety of useful compounds that include natural products and modified peptides. Many methods have been developed to prepare chiral cyclic β-amino acids in high optical purity. This mini-review will discuss some of the most recent and successful approaches.

Keywords: amino acids, cyclic amino acids, enantioselective synthesis, conformationally constrained, peptides, asymmetric synthesis

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Article Details

VOLUME: 2
ISSUE: 1
Year: 2005
Page: [39 - 45]
Pages: 7
DOI: 10.2174/1570193052774117

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