The Enantioselective Synthesis of Conformationally Constrained Cyclic β- Amino Acids

Title: The Enantioselective Synthesis of Conformationally Constrained Cyclic β- Amino Acids

Volume: 2 Issue: 1

Author(s): Jason A. Miller and SonBinh T. Nguyen

Affiliation:

Keywords: amino acids, cyclic amino acids, enantioselective synthesis, conformationally constrained, peptides, asymmetric synthesis

Abstract: Enantiomerically pure and conformationally constrained cyclic β-amino acids have been the subject of a vast amount of research across the chemical, biological, and medicinal disciplines. These valuable molecules are synthetic precursors for a wide variety of useful compounds that include natural products and modified peptides. Many methods have been developed to prepare chiral cyclic β-amino acids in high optical purity. This mini-review will discuss some of the most recent and successful approaches.

Cite this article as:

Miller A. Jason and Nguyen T. SonBinh, The Enantioselective Synthesis of Conformationally Constrained Cyclic β- Amino Acids, Mini-Reviews in Organic Chemistry 2005; 2 (1) . https://dx.doi.org/10.2174/1570193052774117