Interfacial Effects on the Conformation of Amyloid-Beta Peptide

Author(s): Norbert W. Seidler, Joshua D. Eklund

Journal Name: Protein & Peptide Letters

Volume 16 , Issue 2 , 2009


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Abstract:

We examined the effects of air-water and water-sevoflurane interfaces on conformational properties of amyloid- β peptide (ABP). Fractions were extracted from sub-interfacial (air-water) and supra-interfacial (water-sevoflurane) layers and compared with aqueous bulk layers using fluorescence properties of ABP provided by a single tyrosine. The observations suggest that interfacial ABP may be more disordered than bulk ABP.

Keywords: Amyloid-beta, interface, sevoflurane, fluorescence, protein folding

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Article Details

VOLUME: 16
ISSUE: 2
Year: 2009
Page: [182 - 188]
Pages: 7
DOI: 10.2174/092986609787316324
Price: $65

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