Stabilities of 67Ga- and 111In-Labeled Transferrin In Vitro

Author(s): Yosuke Ohtake, Akiko Maruko, Yoshikazu Kuwahara, Manabu Fukumoto, Yasuhito Ohkubo

Journal Name: Protein & Peptide Letters

Volume 16 , Issue 2 , 2009


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Abstract:

We attempted to develop a stable radiolabeled transferrin (Tf) useful in experimental studies related to Tf receptor. 67Ga and 111In were used as labeling radioisotopes. The results from gel chromatography, dialysis, and electrophoresis showed that 111In-DTPA-Tf was the most stable among the radiolabeled Tfs examined in the present study. 111In- DTPA-Tf was also the most stable radiolabeled transferrin in the blood.

Keywords: Transferrin, radiolabeling, DTPA, 67Ga, 111In

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Article Details

VOLUME: 16
ISSUE: 2
Year: 2009
Page: [138 - 142]
Pages: 5
DOI: 10.2174/092986609787316298
Price: $65

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