Molecular Cloning and Expression of Several New Anopheles cracens Epsilon Class Glutathione Transferases

Author(s): Jeerang Wongtraku, Jantana Wongsantichon, Ardcharaporn Vararattanavech, Posri Leelapat, La-aied Prapanthadara, Albert J. Ketterman

Journal Name: Protein & Peptide Letters

Volume 16 , Issue 1 , 2009

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Glutathione transferases, GSTs, are detoxification proteins that are found in most organisms. The acGSTE3-3 had the ability to conjugate 4-hydroxynonenal, a cytotoxic lipid peroxidation product. Although other Epsilon GSTs showed roles in insecticide metabolism, the acGSTE3-3 appeared to have a major role in detoxifying lipid peroxidation products conferring protection against oxidative damage.

Keywords: Glutathione transferase, An. cracens, Epsilon class, 4-HNE, lipid peroxidation, oxidative stress

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Article Details

Year: 2009
Page: [75 - 81]
Pages: 7
DOI: 10.2174/092986609787049367

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