Structural Bioinformatics of Vibrio cholerae Aminopeptidase A (PepA) Monomer

Author(s): Ghosia Lutfullah, Noreen Azhar, Farhat Amin, Zahid Khan, M. Kamran Azim, Khalida Shouqat, Sajid Noor, Rizwan Ali

Journal Name: Protein & Peptide Letters

Volume 16 , Issue 1 , 2009


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Abstract:

Aminopeptidase A (PepA) is a metalloexopeptidase found in Vibrio cholerae .It functions as a transcriptional repressor in regulatory cascade that controls virulence gene expression in V. cholerae. It is involved in protein degradation and in the metabolism of biologically active peptides. We proposed a 3D model of PepA based upon the crystal structure of PepA from Escherichia coli (E. coli) with an intention to evaluate the active site of the enzyme and to predict the properties of this enzyme, study of its 3D structure will help in understanding its role in DNA binding.

Keywords: Aminopeptidase (PepA) Vibrio cholerae, protein degradation, homohexamer, homology modeling, 3D structure, DNA binding

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Article Details

VOLUME: 16
ISSUE: 1
Year: 2009
Page: [36 - 45]
Pages: 10
DOI: 10.2174/092986609787049484

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