Hydroxyl Radical Mediates Oxidative Modification of Caprine Alpha-2 Macroglobulin

Author(s): Shakil A. Khan, Fahim H. Khan

Journal Name: Protein & Peptide Letters

Volume 16 , Issue 1 , 2009

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Abstract:

ROS, including .OH, is now recognized as the hallmark of inflammation and damage to the anti-proteinase barrier has been implicated in a number of pathophysiological conditions. We have previously shown that O2 .- and H2O2/HOCl are physiologically relevant inactivators of α2M, a key anti-proteinase. Here, we show that .OH disrupted caprine α2M structure and antiproteolytic potential in vitro, suggesting that its function could be compromised via oxidative modification.

Keywords: Caprine, alpha-2-macroglobulin, hydroxyl radical

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Article Details

VOLUME: 16
ISSUE: 1
Year: 2009
Page: [32 - 35]
Pages: 4
DOI: 10.2174/092986609787049376

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