Title: Hydroxyl Radical Mediates Oxidative Modification of Caprine Alpha-2 Macroglobulin
VOLUME: 16 ISSUE: 1
Author(s):Shakil A. Khan and Fahim H. Khan
Affiliation:Department of Biochemistry,Faculty of Life Science, Aligarh Muslim Universitry, Aligarh–202002,India.
Keywords:Caprine, alpha-2-macroglobulin, hydroxyl radical
Abstract: ROS, including .OH, is now recognized as the hallmark of inflammation and damage to the anti-proteinase barrier has been implicated in a number of pathophysiological conditions. We have previously shown that O2 .- and H2O2/HOCl are physiologically relevant inactivators of α2M, a key anti-proteinase. Here, we show that .OH disrupted caprine α2M structure and antiproteolytic potential in vitro, suggesting that its function could be compromised via oxidative modification.
