The Novel Role for Lyn in Integrin Signaling in Human Disease

Author(s): Brian Tomkowicz, Andrzej Ptasznik

Journal Name: Current Signal Transduction Therapy

Volume 4 , Issue 1 , 2009

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Cell movement and adhesion serve critical roles in a wide variety of physiological situations, and when dysregulated can contribute to the pathogenesis of many diseases. Recently, Lyn kinase has emerged as a crucial regulator of ‘inside-out’ integrin signaling in hematopoietic cells, that when dysregulated, can lead to the development of an “invasive cell” phenotype in a variety of pathological contexts ranging from leukemia to neuro-inflammatory disorders. Here, we discuss several pathologies associated with perturbations of Lyn-dependent inside-out integrin signaling pathways in blood cells.

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Article Details

Year: 2009
Page: [59 - 65]
Pages: 7
DOI: 10.2174/157436209787048685

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PDF: 19