Title: The Novel Role for Lyn in Integrin Signaling in Human Disease
VOLUME: 4 ISSUE: 1
Author(s):Brian Tomkowicz and Andrzej Ptasznik
Affiliation:130 Barren Rd,. Newtown Sq., PA 19073, USA.
Abstract: Cell movement and adhesion serve critical roles in a wide variety of physiological situations, and when dysregulated can contribute to the pathogenesis of many diseases. Recently, Lyn kinase has emerged as a crucial regulator of ‘inside-out’ integrin signaling in hematopoietic cells, that when dysregulated, can lead to the development of an “invasive cell” phenotype in a variety of pathological contexts ranging from leukemia to neuro-inflammatory disorders. Here, we discuss several pathologies associated with perturbations of Lyn-dependent inside-out integrin signaling pathways in blood cells.
