Solution-Phase Parallel Synthesis of N-Arylisoquinuclidines

Title: Solution-Phase Parallel Synthesis of N-Arylisoquinuclidines

Volume: 6 Issue: 1

Author(s): Ronald F. Borne, Mark S. Levi, M. O. Faruk Khan and Norman H. Wilson

Affiliation:

Keywords: Addiction, Ibogaine, Isoquinuclidine, Parallel synthesis, Anti-addictive

Abstract: The naturally-occurring alkaloid ibogaine, found in the West African shrub Tabernanthe iboga, possesses the ability to diminish self-administration of substances of abuse, such as cocaine, heroin and alcohol. The presence of the isoquinuclidine ring system in the structure of ibogaine became the lead for the design of a 16-member library of N-aryl isoquinuclidines, where pyridine, pyrimidine and quinoline ring systems were attached directly to the bicyclic nitrogen. A solution-phase method for their synthesis is described.

Cite this article as:

Borne F. Ronald, Levi S. Mark, Faruk Khan O. M. and Wilson H. Norman, Solution-Phase Parallel Synthesis of N-Arylisoquinuclidines, Letters in Drug Design & Discovery 2009; 6 (1) . https://dx.doi.org/10.2174/157018009787158517