Solution-Phase Parallel Synthesis of N-Arylisoquinuclidines

Author(s): Ronald F. Borne, Mark S. Levi, M. O. Faruk Khan, Norman H. Wilson

Journal Name: Letters in Drug Design & Discovery

Volume 6 , Issue 1 , 2009

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Abstract:

The naturally-occurring alkaloid ibogaine, found in the West African shrub Tabernanthe iboga, possesses the ability to diminish self-administration of substances of abuse, such as cocaine, heroin and alcohol. The presence of the isoquinuclidine ring system in the structure of ibogaine became the lead for the design of a 16-member library of N-aryl isoquinuclidines, where pyridine, pyrimidine and quinoline ring systems were attached directly to the bicyclic nitrogen. A solution-phase method for their synthesis is described.

Keywords: Addiction, Ibogaine, Isoquinuclidine, Parallel synthesis, Anti-addictive

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Article Details

VOLUME: 6
ISSUE: 1
Year: 2009
Page: [78 - 81]
Pages: 4
DOI: 10.2174/157018009787158517

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