Synthesis and Antitumor Activity of Novel 4-Chloro-3-Arylmaleimide Derivatives

Author(s): Guiqing Xu, Qiaojun He, Bo Yang, Yongzhou Hu

Journal Name: Letters in Drug Design & Discovery

Volume 6 , Issue 1 , 2009

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Abstract:

A novel series of 4-chloro-3-arylmaleimide derivatives have been synthesized and evaluated for their cytotoxicity in vitro against human leukemia cell line and four human solid cancer cell lines. Most compounds showed high or mediate activity against the cancer cell lines when compared with bisindolylmaleimide. Among them, 4b is the most promising compound.

Keywords: 4-chloro-3-arylmaleimide, Synthesis, Antitumor activity

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Article Details

VOLUME: 6
ISSUE: 1
Year: 2009
Page: [51 - 55]
Pages: 5
DOI: 10.2174/157018009787158490

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