Identification of GCP II Inhibitors Based on 4-Arylmethyl-3-(4- carboxyphenyl)-5-hydroxyisoxazole Scaffold

Author(s): M. Teus, A. Jirgensons, M. Dambrova, R. Mezhapuke, C. G. Parsons, W. Danysz

Journal Name: Letters in Drug Design & Discovery

Volume 6 , Issue 1 , 2009

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Screening of a non-ionizable compound library and hit optimization studies has resulted in a series of compounds based on a 4-arylmethyl-3-(4-carboxyphenyl)-5-hydroxyisoxazole scaffold with GCP II inhibitory activity in the low micromolar range.

Keywords: Glutamate carboxypeptidase II, Glutamate, 5-hydroxyisoxazole, Lipophilicity, Synthesis

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Article Details

Year: 2009
Page: [29 - 32]
Pages: 4
DOI: 10.2174/157018009787158544

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