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Letters in Drug Design & Discovery

Editor-in-Chief

ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

Identification of GCP II Inhibitors Based on 4-Arylmethyl-3-(4- carboxyphenyl)-5-hydroxyisoxazole Scaffold

Author(s): M. Teus, A. Jirgensons, M. Dambrova, R. Mezhapuke, C. G. Parsons and W. Danysz

Volume 6, Issue 1, 2009

Page: [29 - 32] Pages: 4

DOI: 10.2174/157018009787158544

Price: $65

Abstract

Screening of a non-ionizable compound library and hit optimization studies has resulted in a series of compounds based on a 4-arylmethyl-3-(4-carboxyphenyl)-5-hydroxyisoxazole scaffold with GCP II inhibitory activity in the low micromolar range.

Keywords: Glutamate carboxypeptidase II, Glutamate, 5-hydroxyisoxazole, Lipophilicity, Synthesis


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