Role of Metal Ions in the Aβ Oligomerization in Alzheimers Disease and in Other Neurological Disorders

Author(s): D. Drago, S. Bolognin, P. Zatta

Journal Name: Current Alzheimer Research

Volume 5 , Issue 6 , 2008

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Neurodegeneration is a complex and multifaceted process leading to many chronic diseased states. Neurodegenerative disorders include a number of different pathological conditions, like Alzheimers and Parkinsons diseases, which share similar critical metabolic processes, such as protein aggregation, which could be affected by some metal ions. A huge number of reports indicate that, among putative aggravating factors, metal ions (Al, Zn, Cu, Fe) could specifically impair protein aggregation of Aβ, prion protein, ataxin, huntingtin, etc. and their oligomeric toxicity. While studying the molecular basis of these diseases, it has become clear that protein conformation plays a critical role in the pathogenic process. In this review, we will focus on Alzheimers disease and on the role of metal ions, specifically aluminium, in affecting amyloid aggregation, oligomerization and toxicity.

Keywords: Alzheimer's disease, amyloid, aggregation, oligomers, metal ions

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Article Details

Year: 2008
Page: [500 - 507]
Pages: 8
DOI: 10.2174/156720508786898479
Price: $65

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