Abstract
We report herein the synthesis of a series of eight novel compounds based on the coupling of 6-mercaptopurine (4), 2-mercaptopyrimidine (5), 4-mercaptopyridine (6) and 2-mercaptobenzimidazole (7) with 6-deoxy-6-iodo-1,2:3,4-di- O-isopropylidene-γ-D-psicofuranose and subsequent deprotection. The compounds were evaluated in vitro for activity against Leishmania amazonensis and L. chagasi promastigotes and for cytotoxic activity against Kb and Vero cells.
Keywords: D-psicofuranose, 6-mercaptopurine, 2-mercaptopyrimidine, 4-mercaptopyridine, 2-mercaptobenzimidazole
Letters in Drug Design & Discovery
Title: Synthesis and Biological Evaluation of Novel 6-Deoxy-β -D-Psicofuranosyl Mercaptoheterocyclic Compounds
Volume: 5 Issue: 8
Author(s): I. G. De Lade, F. G. Braga, R. M. Grazul, E. S. Coimbra and A. D. Da Silva
Affiliation:
Keywords: D-psicofuranose, 6-mercaptopurine, 2-mercaptopyrimidine, 4-mercaptopyridine, 2-mercaptobenzimidazole
Abstract: We report herein the synthesis of a series of eight novel compounds based on the coupling of 6-mercaptopurine (4), 2-mercaptopyrimidine (5), 4-mercaptopyridine (6) and 2-mercaptobenzimidazole (7) with 6-deoxy-6-iodo-1,2:3,4-di- O-isopropylidene-γ-D-psicofuranose and subsequent deprotection. The compounds were evaluated in vitro for activity against Leishmania amazonensis and L. chagasi promastigotes and for cytotoxic activity against Kb and Vero cells.
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Cite this article as:
De Lade G. I., Braga G. F., Grazul M. R., Coimbra S. E. and Da Silva D. A., Synthesis and Biological Evaluation of Novel 6-Deoxy-β -D-Psicofuranosyl Mercaptoheterocyclic Compounds, Letters in Drug Design & Discovery 2008; 5 (8) . https://dx.doi.org/10.2174/157018008786898554
DOI https://dx.doi.org/10.2174/157018008786898554 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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