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Letters in Drug Design & Discovery

Editor-in-Chief

ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

Synthesis and Biological Evaluation of Novel 6-Deoxy-β -D-Psicofuranosyl Mercaptoheterocyclic Compounds

Author(s): I. G. De Lade, F. G. Braga, R. M. Grazul, E. S. Coimbra and A. D. Da Silva

Volume 5, Issue 8, 2008

Page: [481 - 484] Pages: 4

DOI: 10.2174/157018008786898554

Price: $65

Abstract

We report herein the synthesis of a series of eight novel compounds based on the coupling of 6-mercaptopurine (4), 2-mercaptopyrimidine (5), 4-mercaptopyridine (6) and 2-mercaptobenzimidazole (7) with 6-deoxy-6-iodo-1,2:3,4-di- O-isopropylidene-γ-D-psicofuranose and subsequent deprotection. The compounds were evaluated in vitro for activity against Leishmania amazonensis and L. chagasi promastigotes and for cytotoxic activity against Kb and Vero cells.

Keywords: D-psicofuranose, 6-mercaptopurine, 2-mercaptopyrimidine, 4-mercaptopyridine, 2-mercaptobenzimidazole


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