Abstract
Recent data from a series of laboratories has pinpointed the relevant role of translation control on the regulation of gene expression. In particular, an analysis of T cell activation has led to demonstrate that during this physiological transition about 20% of the regulated mRNAs are controlled at the translation level. Furthermore, modulating the host mRNA translation is one of the mechanisms used by infectious agents to achieve a productive infection. In the present review, we summarize the current knowledge on the translation machinery, the translational control mechanisms during the immune response, as well as the mechanisms used by different pathogens to avoid, inhibit or postpone the host response; and suggest that the analysis on genome-wide screening of the host-pathogen interactions, identifying translationally regulated mRNAs, might unravel new drug targets in infectious diseases.
Keywords: Infectious Diseases, mRNAs, translation control, T cell, immune response, host-pathogen interactions, drug targets
Infectious Disorders - Drug Targets
Title: Translation Controlled mRNAs: New Drug Targets in Infectious Diseases?
Volume: 8 Issue: 4
Author(s): Eva Diaz-Guerra, Rolando Vernal, Walter Cantero, Ernst W. Mullner and Jose A. Garcia- Sanz
Affiliation:
Keywords: Infectious Diseases, mRNAs, translation control, T cell, immune response, host-pathogen interactions, drug targets
Abstract: Recent data from a series of laboratories has pinpointed the relevant role of translation control on the regulation of gene expression. In particular, an analysis of T cell activation has led to demonstrate that during this physiological transition about 20% of the regulated mRNAs are controlled at the translation level. Furthermore, modulating the host mRNA translation is one of the mechanisms used by infectious agents to achieve a productive infection. In the present review, we summarize the current knowledge on the translation machinery, the translational control mechanisms during the immune response, as well as the mechanisms used by different pathogens to avoid, inhibit or postpone the host response; and suggest that the analysis on genome-wide screening of the host-pathogen interactions, identifying translationally regulated mRNAs, might unravel new drug targets in infectious diseases.
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Cite this article as:
Diaz-Guerra Eva, Vernal Rolando, Cantero Walter, Mullner W. Ernst and Garcia- Sanz A. Jose, Translation Controlled mRNAs: New Drug Targets in Infectious Diseases?, Infectious Disorders - Drug Targets 2008; 8 (4) . https://dx.doi.org/10.2174/187152608786734205
DOI https://dx.doi.org/10.2174/187152608786734205 |
Print ISSN 1871-5265 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3989 |
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