Medicinal Chemistry Approaches to the Inhibition of Dipeptidyl Peptidase IV

Author(s): Stephen L. Gwaltney II

Journal Name: Current Topics in Medicinal Chemistry

Volume 8 , Issue 17 , 2008

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Inhibitors of dipeptidyl peptidase IV (DPP-4) have emerged as an important new class of therapeutic agents for type two diabetes. Various medicinal chemistry approaches have been applied to this area and have resulted in the identification of numerous late-stage development compounds. The discoveries of several of the most advanced DPP-4 inhibitors are reviewed.

Keywords: Dipeptidyl Peptidase IV (DPP-4), Glucagon-like Peptide-1 (GLP-1), vildagliptin (Galvus®), saxagliptin (Onglyza™), sitagliptin (Januvia™), linagliptin (Ondero®), alogliptin

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Article Details

Year: 2008
Published on: 01 March, 2012
Page: [1545 - 1552]
Pages: 8
DOI: 10.2174/156802608786413519
Price: $65

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