Recent Advances on Cyclopeptide-Based Glycoclusters

Author(s): Olivier Renaudet

Journal Name: Mini-Reviews in Organic Chemistry

Volume 5 , Issue 4 , 2008


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Abstract:

Many important biological processes including fertilization, tissue formation, cell adhesion, antigen/antibody interactions, cancer metastasis or pathogen infection involve polyvalent interactions between oligomeric proteins and carbohydrate-based ligands. The synthesis of multitopic, molecularly-defined structures that display both clustered sugars and immobilization or bioactive agents represents an attractive approach for the discovery of new diagnostics and therapeutics. This mini-review updates the current developments in this field by focusing on the recent interests on cyclopeptide-based glycoclusters.

Keywords: Cyclopeptide, glycocluster, multivalency, carbohydrate, solid-phase synthesis, oxime ligation

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Article Details

VOLUME: 5
ISSUE: 4
Year: 2008
Page: [274 - 286]
Pages: 13
DOI: 10.2174/157019308786242142
Price: $65

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