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Mini-Reviews in Organic Chemistry

Editor-in-Chief

ISSN (Print): 1570-193X
ISSN (Online): 1875-6298

Recent Advances on Cyclopeptide-Based Glycoclusters

Author(s): Olivier Renaudet

Volume 5, Issue 4, 2008

Page: [274 - 286] Pages: 13

DOI: 10.2174/157019308786242142

Price: $65

Abstract

Many important biological processes including fertilization, tissue formation, cell adhesion, antigen/antibody interactions, cancer metastasis or pathogen infection involve polyvalent interactions between oligomeric proteins and carbohydrate-based ligands. The synthesis of multitopic, molecularly-defined structures that display both clustered sugars and immobilization or bioactive agents represents an attractive approach for the discovery of new diagnostics and therapeutics. This mini-review updates the current developments in this field by focusing on the recent interests on cyclopeptide-based glycoclusters.

Keywords: Cyclopeptide, glycocluster, multivalency, carbohydrate, solid-phase synthesis, oxime ligation


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