The Role of Structure Activity Relationship Studies in the Search for New GABA Uptake Inhibitors

Author(s): Katarzyna Kulig, Marta Szwaczkiewicz

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 8 , Issue 12 , 2008

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γ-Aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian central nervous system (CNS). A decrease in GABAergic neurotransmission seems to be involved in neurological pathologies such as epilepsy, anxiety and pain. This review is focus on structure activity relationship studies aiming the search for new GABA uptake inhibitors.

Keywords: γ-Aminobutyric acid, GABA, GABA uptake antagonist, GABA transporter, GAT

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Article Details

Year: 2008
Published on: 01 March, 2012
Page: [1214 - 1223]
Pages: 10
DOI: 10.2174/138955708786141070
Price: $65

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