Caldesmon as a Therapeutic Target for Proliferative Vascular Diseases

Author(s): Chi-Ming Hai

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 8 , Issue 12 , 2008

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Caldesmon is a negative regulator of cell proliferation, migration, and metalloproteinase release. Caldesmon function is regulated by multiple kinases, targeting multiple phosphorylation sites. Recently, overexpression of caldesmon has been shown to inhibit neointimal formation after experimental angioplasty, suggesting that caldesmon may be a potential therapeutic target for proliferative vascular diseases.

Keywords: Actin, atherosclerosis, caldesmon, calmodulin, restenosis, vascular smooth muscle

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Article Details

Year: 2008
Page: [1209 - 1213]
Pages: 5
DOI: 10.2174/138955708786140981
Price: $65

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