Concerted Action of Metals and Macromolecular Crowding on the Fibrillation of α-Synuclein

Author(s): Larissa A. Munishkina, Anthony L. Fink, Vladimir N. Uversky

Journal Name: Protein & Peptide Letters

Volume 15 , Issue 10 , 2008

Become EABM
Become Reviewer


Certain metals lead to increased risk of Parkinsons disease (PD) and the aggregation of α-synuclein is implicated in the PD pathology. Although α-synuclein fibrillation has been extensively studied in dilute solutions in vitro, the intracellular environment is highly crowded. We are showing here that certain metals cause a significant acceleration of α-synuclein fibrillation in the presence of high concentrations of various macromolecules mostly through decreasing the fibrillation lagtime. The faster fibrillation in crowded environments in the presence of heavy metals suggests a simple molecular basis for the observed elevated risk of PD due to exposure to metals.

Keywords: Parkinson's disease, α-synuclein, crowding, fibrillation, aggregation, metals

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2008
Page: [1079 - 1085]
Pages: 7
DOI: 10.2174/092986608786071102
Price: $65

Article Metrics

PDF: 4