Abstract
Irradiation of hyperforin in acetonitrile gave a single degradation product with a first order kinetics (k = 3.23 M h-1). The degradation product was a 1:1 tautomeric mixture of 2-methyl-3-hydroxy-4-(1-oxo-2-methyl-1-propyl)-1,5- dioxo-6-(3methyl-1-but-2-enyl)-2-cyclohexene and 2-methyl-1,3,5-trioxo-4-(1-hydroxy-2-methyl-1-propylene)-6-(3-methyl- 1-but-2-enyl)-cyclohexane. The product can also be obtained through three Norrish II reactions, followed by a fragmentation reaction.
Keywords: Photochemical Degradation, Hyperforin, Irradiation, acetonitrile, first order kinetics, tautomeric mixture, three Norrish II reactions, fragmentation reaction
Letters in Organic Chemistry
Title: Photochemical Degradation of Hyperforin
Volume: 5 Issue: 7
Author(s): Maurizio D'Auria, Lucia Emanuele and Rocco Racioppi
Affiliation:
Keywords: Photochemical Degradation, Hyperforin, Irradiation, acetonitrile, first order kinetics, tautomeric mixture, three Norrish II reactions, fragmentation reaction
Abstract: Irradiation of hyperforin in acetonitrile gave a single degradation product with a first order kinetics (k = 3.23 M h-1). The degradation product was a 1:1 tautomeric mixture of 2-methyl-3-hydroxy-4-(1-oxo-2-methyl-1-propyl)-1,5- dioxo-6-(3methyl-1-but-2-enyl)-2-cyclohexene and 2-methyl-1,3,5-trioxo-4-(1-hydroxy-2-methyl-1-propylene)-6-(3-methyl- 1-but-2-enyl)-cyclohexane. The product can also be obtained through three Norrish II reactions, followed by a fragmentation reaction.
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Cite this article as:
D'Auria Maurizio, Emanuele Lucia and Racioppi Rocco, Photochemical Degradation of Hyperforin, Letters in Organic Chemistry 2008; 5 (7) . https://dx.doi.org/10.2174/157017808785982112
DOI https://dx.doi.org/10.2174/157017808785982112 |
Print ISSN 1570-1786 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6255 |
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