Design of Selective G-quadruplex Ligands as Potential Anticancer Agents

Author(s): Jia-Heng Tan, Lian-Quan Gu, Jian-Yong Wu

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 8 , Issue 11 , 2008

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G-quadruplex structures are promising targets for design of cancer drugs with high selectivity and low toxicity. This review provides an update of the progress made over the last few years in the design of selective G-quadruplex ligands, and a comprehensive summary of the major design strategies and structural characteristics.

Keywords: G-quadruplex, G-quartet, ligands, substituted derivatives, affinity and selectivity, DNA interactions, telomerase inhibition

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Article Details

Year: 2008
Page: [1163 - 1178]
Pages: 16
DOI: 10.2174/138955708785909880
Price: $65

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