Hyperglycemia-Related Pathophysiologic Mechanisms and Potential Beneficial Actions of Melatonin

Author(s): Ahmet Korkmaz, Turgut Topal, Sukru Oter, Dun-Xian Tan, Russel J. Reiter

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 8 , Issue 11 , 2008

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Chronically-elevated blood glucose initiates a harmful series of processes in which toxic reactive species play crucial roles. Oxidative as well as nitro-oxidative stress is harmful for virtually all biomolecules including lipids, proteins and DNA. Such pathophysiologic mechanisms eventually results in cellular dysfunction, apoptosis or necrosis. Melatonin is a multifunctional indolamine which counteracts several pathophysiologic steps and displays significant beneficial effects against hyperglycemia-induced cellular toxicity. These are related to melatonins antioxidative, anti-inflammatory and possibly epigenetic regulatory properties. Current knowledge encourages using this non-toxic indolamine either as a sole treatment or in conjunction with other treatments for inhibition of the biohazards of hyperglycemia.

Keywords: Hyperglycemia, free radicals, peroxynitrite, DNA damage, melatonin

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Article Details

Year: 2008
Page: [1144 - 1153]
Pages: 10
DOI: 10.2174/138955708785909925
Price: $65

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