Depsipeptides from Microorganisms: A New Class of Antimalarials

Author(s): Jean Fotie, Rachel E. Morgan

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 8 , Issue 11 , 2008

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Depsipeptides are a large group of natural products produced by fungi, actinomycetes, cyanobacteria, higher plants and marine organisms. This family of compounds is known to exhibit a wide range of biological activities, and thanks to the progress of isolation techniques and the advances of methods for structure determination, the numbers of depsipeptides having both unique structures and attractive biological activities are increasing. Many of these compounds have shown a wide range of biological activities, and some are in clinical use or have entered human clinical trials as antibiotic or anticancer agents. However, only a handful of them have been evaluated for their antimalarial activity. This paper aims to review the recent advances in depsipeptides as potential antimalarial compounds.

Keywords: Depsipeptides, Microorganisms, Antimalarials, actinomycetes, cyanobacteria, marine organisms, biological activities, isolation techniques, anticancer agents

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Article Details

Year: 2008
Page: [1088 - 1094]
Pages: 7
DOI: 10.2174/138955708785909916
Price: $65

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