Urease and α-Chymotrypsin Inhibitory Effects of Selected Urea Derivatives

Author(s): Shahnaz Perveen, Khalid Mohammed Khan, Muhammad Arif Lodhi, Muhammad Iqbal Choudhary, Atta-ur-Rahman, Wolfgang Voelter

Journal Name: Letters in Drug Design & Discovery

Volume 5 , Issue 6 , 2008

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A number of urea derivatives were synthesized and screened for their urease and α-chymotrypsin inhibition effects, whereby one of the compounds, N-4-nitrophenyl-N’-4’-nitrophenylurea (3), showed strong urease inhibition (IC50 = 1.25μM). We found that the same compound is also an efficient α-chymotrypsin inhibitor having an IC50 value of 3.15μM.

Keywords: Urease, α-chymotrypsin, Urea derivatives

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Article Details

Year: 2008
Page: [401 - 405]
Pages: 5
DOI: 10.2174/157018008785777315
Price: $65

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