A Preliminary Assessment of the Structure-Activity Relationship of Benzimidazole-Based Anti-Proliferative Agents

Title: A Preliminary Assessment of the Structure-Activity Relationship of Benzimidazole-Based Anti-Proliferative Agents

Volume: 5 Issue: 6

Author(s): Leyte L. Winfield, Dayle M. Smith, Kalani Halemano and Carmine S. Leggett

Affiliation:

Keywords: 3D Pharmacophore, Benzimidazole, PDK1, Prostate cancer, SAR, Anti-proliferative

Abstract: PDK1 is pivotal in the development and progression of several cancers. A 3D pharmacophore was developed for pyrazole derivatives displaying anti-proliferative activity and PDK1 inhibition. The pharmacophore was utilized in the design of benzimidazole analogs. Our preliminary results indicate the pharmacophore should be useful in designing PDK1 inhibitors and anti-proliferative agents.

Cite this article as:

Winfield L. Leyte, Smith M. Dayle, Halemano Kalani and Leggett S. Carmine, A Preliminary Assessment of the Structure-Activity Relationship of Benzimidazole-Based Anti-Proliferative Agents, Letters in Drug Design & Discovery 2008; 5 (6) . https://dx.doi.org/10.2174/157018008785777324