Abstract
The rapid expansion in the past two decades in the understanding of the molecular basis of a large variety of novel congenital immunodeficiencies has provided valuable information on the signal transduction general mechanisms, that goes far beyond the comprehension of the individual disease. In most cases, the altered molecules are exclusively expressed in haematopoietic cells, while in other cases they are not restricted to a certain cell type. This leads to more complex clinical phenotypes, which contribute to unravel previously unappreciated non-haematopoietic functions of signaling proteins and the mechanism of coordination and integration of several pathways. Moreover, this knowledge will help define potential new therapeutic strategies through novel molecular targets, drive stem cell development into the desired differentiation path and ameliorate our comprehension of tissue engineering. This review focuses on the multiple roles in haematopoietic and non-haematopoietic receptors of the gamma signaling element with a special attention paid to the participation of gamma to growth hormone receptor signaling, confirming the presence of an interplay between endocrine and immune system.
Keywords: Congenital immunodeficiencies, growth hormone receptor, signal transduction, gamma chain, STATs
Current Signal Transduction Therapy
Title: Shared Signaling Pathways Between Endocrine and Immune System Receptors: The Model of Gamma Chain
Volume: 3 Issue: 3
Author(s): Claudio Pignata, Stefania Amorosi, Ilaria Russo, Donatella Capalbo, Teresa Lettiero, Marsilio Adriani and Mariacarolina Salerno
Affiliation:
Keywords: Congenital immunodeficiencies, growth hormone receptor, signal transduction, gamma chain, STATs
Abstract: The rapid expansion in the past two decades in the understanding of the molecular basis of a large variety of novel congenital immunodeficiencies has provided valuable information on the signal transduction general mechanisms, that goes far beyond the comprehension of the individual disease. In most cases, the altered molecules are exclusively expressed in haematopoietic cells, while in other cases they are not restricted to a certain cell type. This leads to more complex clinical phenotypes, which contribute to unravel previously unappreciated non-haematopoietic functions of signaling proteins and the mechanism of coordination and integration of several pathways. Moreover, this knowledge will help define potential new therapeutic strategies through novel molecular targets, drive stem cell development into the desired differentiation path and ameliorate our comprehension of tissue engineering. This review focuses on the multiple roles in haematopoietic and non-haematopoietic receptors of the gamma signaling element with a special attention paid to the participation of gamma to growth hormone receptor signaling, confirming the presence of an interplay between endocrine and immune system.
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Cite this article as:
Pignata Claudio, Amorosi Stefania, Russo Ilaria, Capalbo Donatella, Lettiero Teresa, Adriani Marsilio and Salerno Mariacarolina, Shared Signaling Pathways Between Endocrine and Immune System Receptors: The Model of Gamma Chain, Current Signal Transduction Therapy 2008; 3 (3) . https://dx.doi.org/10.2174/157436208785699695
DOI https://dx.doi.org/10.2174/157436208785699695 |
Print ISSN 1574-3624 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-389X |
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