Molecular Structural Characteristics of Estrogen Receptor Modulators as Determinants of Estrogen Receptor Selectivity

Author(s): S. Agatonovic-Kustrin, J. V. Turner

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 8 , Issue 9 , 2008


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Abstract:

This review will discuss the structural determinants and requirements necessary for estrogen receptors alpha and beta selectivity and ligand-receptor binding affinity. In addition, strategies likely to result in the development of a pharmacophore model that account for the differences in estrogenic effects between different ligands will be discussed.

Keywords: Computer aided drug design, molecular modeling, structure-activity relationship, hormones, drug design, structure, QSAR, phytoestrogens

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Article Details

VOLUME: 8
ISSUE: 9
Year: 2008
Page: [943 - 951]
Pages: 9
DOI: 10.2174/138955708785132747
Price: $65

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