Apoptosis in Atherosclerosis: A Mini-Review

Author(s): Maria Karaflou, Irene Lambrinoudaki, George Christodoulakos

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 8 , Issue 9 , 2008

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Apoptosis in atherosclerotic lesions is triggered by inflammatory processes, both via cell-cell contact and by cytokines and oxidized lipids. The role of apoptosis in atherogenesis is dual, depending on the stage of the plaque: In early stages, apoptotic death of smooth muscle - and inflammatory cells, such as lymphocytes and macrophages, may delay atherosclerotic process. However, once the plaque is formed, apoptosis may lead to plaque rupture and thrombosis.

Keywords: Atherosclerosis, apoptosis, pathogenesis

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Article Details

Year: 2008
Published on: 01 March, 2012
Page: [912 - 918]
Pages: 7
DOI: 10.2174/138955708785132765
Price: $65

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PDF: 9