Title: Small Molecules Targeting p53 to Improve Antitumor Therapy
VOLUME: 8 ISSUE: 9
Author(s):G. L. Beretta, L. Gatti, V. Benedetti, P. Perego and F. Zunino
Affiliation:Fondazione IRCCS Istituto Nazionale Tumori, ViaVenezian 1, 20133Milan, Italy.
Keywords:p53, nutlins, pifithrins, histone deacetylase inhibitors, ubiquitin ligase inhibitors, apoptosis, cancer cells, drug combination
Abstract: Small molecules targeting p53 represent an emerging group of potentially useful agents for the improvement of antitumor therapy. These modulators include agents that activate wild-type p53 or reactivate mutant p53 and inhibitors of p53 functions. Preclinical evidences support the interest of combination strategies with conventional antitumor agents.
