Small Molecules Targeting p53 to Improve Antitumor Therapy

Author(s): G. L. Beretta, L. Gatti, V. Benedetti, P. Perego, F. Zunino

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 8 , Issue 9 , 2008

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Abstract:

Small molecules targeting p53 represent an emerging group of potentially useful agents for the improvement of antitumor therapy. These modulators include agents that activate wild-type p53 or reactivate mutant p53 and inhibitors of p53 functions. Preclinical evidences support the interest of combination strategies with conventional antitumor agents.

Keywords: p53, nutlins, pifithrins, histone deacetylase inhibitors, ubiquitin ligase inhibitors, apoptosis, cancer cells, drug combination

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Article Details

VOLUME: 8
ISSUE: 9
Year: 2008
Page: [856 - 868]
Pages: 13
DOI: 10.2174/138955708785132774
Price: $65

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