Title: From Dual Binding Site Acetylcholinesterase Inhibitors to Multi-Target-Directed Ligands (MTDLs): A Step Forward in the Treatment of Alzheimers Disease
VOLUME: 8 ISSUE: 10
Author(s):Maria Laura Bolognesi, Anna Minarini, Michela Rosini, Vincenzo Tumiatti and Carlo Melchiorre
Affiliation:Department of Pharmaceutical Sciences, Alma Mater Studiorum, University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy.
Keywords:Dimeric compounds, bivalent ligands, multimodal therapeutics, multifunctional compounds, multifactorial diseases
Abstract: Alzheimers disease is a complex neurodegenerative disorder with a multifaceted pathogenesis. This fact has long halted the development of effective anti-Alzheimer drugs. Recently, however, basis for a therapeutic strategy based on multi-target-directed ligands has been formed. In this context, dual binding site acetylcholinesterase inhibitors represent a suitable starting point. The rational modification of their structures to provide them with additional biological properties has emerged as a successful approach.
