In recent years, the role of C-reactive protein (CRP) in cardiovascular disease has been a lively topic of debate. The reasons for this interest can be summarized as follows. First, CRP has been identified as a powerful cardiovascular risk marker. Second, CRP may not only be a cardiovascular risk marker but also a risk factor, i.e., it may be causally involved in atherogenesis and its sequelae. Third, if it is indeed a cardiovascular risk factor, CRP may be a therapeutic target for primary or secondary prevention of cardiovascular disease. The medical and economic impact of these possibilities is evident. However, despite considerable research, the key questions concerning the role of CRP in cardiovascular disease remain unanswered.