Hormonal Status Modifies Renin-Angiotensin System-Regulating Aminopeptidases andVasopressin-DegradingActivity in the Hypothalamus-Pituitary-Adrenal Axis of Female Mice

Author(s): Maria Jesus Garcia, Jose Manuel Martinez-Martos, Maria Dolores Mayas, Maria Pilar Carrera, Susana De la Chica, Pedro Cortes, Maria Jesus Ramirez-Exposito

Journal Name: Medicinal Chemistry

Volume 4 , Issue 4 , 2008

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Abstract:

The hypothalamus-pituitary-adrenal axis (HPA) participates in the maintenance of cardiovascular functions and in the control of blood pressure. By other hand, it is known that blood pressure regulation and HPA activity are affected by sex hormones. The aim of the present work is to analyze the influence of estradiol and progesterone on reninangiotensin system (RAS)-regulating aminopeptidase A, aminopeptidase B and aminopeptidase N activities and vasopressin- degrading activity in the HPA axis of ovariectomized mice and ovariectomized mice treated subscutaneously with different doses of estradiol and progesterone. Our data suggest that in female mice, estradiol and progesterone influence RAS-regulating and vasopressin-degrading activities at different levels of the HPA axis.

Keywords: Aminopeptidases, sex, estradiol, progesterone, renin-angiotensin system, vasopressin, hypothalamus-pituitaryaxis

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Article Details

VOLUME: 4
ISSUE: 4
Year: 2008
Page: [336 - 347]
Pages: 12
DOI: 10.2174/157340608784872271
Price: $65

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