Synthesis and Biological Evaluation of a New Series of Benzothiazole-Quinolone Hybrids as Antibacterial Agents

Author(s): Ahmed Kamal, S. Kaleem Ahmed, M. Naseer A. Khan, Rajesh V.C.R.N.C. Shetty, B. Siddhardha, U. S.N. Murty

Journal Name: Letters in Drug Design & Discovery

Volume 5 , Issue 5 , 2008

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In an effort to develop new and more effective therapies to treat bacterial infection, quinolone coupled benzothiazoles (6a-f) have prepared and evaluated for their efficacy as antibacterial agents against various Gram-positive and Gram-negative strains of bacteria. Some of the compounds from this series exhibited antibacterial activity comparable to ciprofloxacin.

Keywords: Benzothiazoles, Quinolones, Antibacterial activity

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Article Details

Year: 2008
Page: [353 - 357]
Pages: 5
DOI: 10.2174/157018008784912072
Price: $65

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