Medicinal Chemistry of Hsp90 Inhibitors

Author(s): Martin J. Drysdale, Paul A. Brough

Journal Name: Current Topics in Medicinal Chemistry

Volume 8 , Issue 10 , 2008

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Heat shock protein (Hsp90) inhibitors are an increasingly interesting and important class of compounds where the first in class, natural product derived inhibitors such as 17-allylaminogeldanamycin (17-AAG), are entering late stage clinical development. Recently the emergence of synthetic, small molecule inhibitors has been described and both NVPAUY922 and BIIB021 have entered clinical development. The medicinal chemistry of these and other published small molecule Hsp90 inhibitors is described in this review.

Keywords: Hsp90, anti-cancer, structure-based design

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Article Details

Year: 2008
Page: [859 - 868]
Pages: 10
DOI: 10.2174/156802608784911644
Price: $65

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