Title: Medicinal Chemistry of Hsp90 Inhibitors
VOLUME: 8 ISSUE: 10
Author(s):Martin J. Drysdale and Paul A. Brough
Affiliation:Vernalis R Ltd., Granta Park, Great Abington, Cambridge CB21 6GB, U.K.
Keywords:Hsp90, anti-cancer, structure-based design
Abstract: Heat shock protein (Hsp90) inhibitors are an increasingly interesting and important class of compounds where the first in class, natural product derived inhibitors such as 17-allylaminogeldanamycin (17-AAG), are entering late stage clinical development. Recently the emergence of synthetic, small molecule inhibitors has been described and both NVPAUY922 and BIIB021 have entered clinical development. The medicinal chemistry of these and other published small molecule Hsp90 inhibitors is described in this review.
