Endothelins Role in the Control of the Acute Phase of Trypanosoma cruzi Infection

Author(s): Conceicao R.S. Machado, Elizabeth R.S. Camargos

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 8 , Issue 8 , 2008

Become EABM
Become Reviewer
Call for Editor


Disturbances of endothelin production or clearance contribute to the pathophysiology of several cardiovascular diseases including Chagas disease cardiomyopathy caused by the protozoan Trypanosoma cruzi. In rats, endothelins contribute to control the acute phase, probably by stimulating nitric oxide production. We point out the necessity for new studies to better evaluate high levels of endothelin in the course of other infectious diseases, for which only its detrimental effects have been emphasized.

Keywords: Chagas Disease, cardiomyopathy, cytokines, chemokines, nitric oxide, endothelins, endothelial dysfunction, infectious disease

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2008
Page: [820 - 827]
Pages: 8
DOI: 10.2174/138955708784912184
Price: $65

Article Metrics

PDF: 2