Nociceptin/Orphanin FQ Peptide Receptor as a Therapeutic Target for Obesity

Author(s): Magdalena J. Przydzial, Lora K. Heisler

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 8 , Issue 8 , 2008

Become EABM
Become Reviewer
Call for Editor


Nociceptin/orphanin FQ (N/OFQ) peptide (NOP) receptor is a candidate target for novel therapeutics for a range of conditions, including obesity. This article reviews recent advances in understanding of N/OFQs involvement in the regulation of food intake and appraises current developments in the rational design of antagonists aimed at the NOP receptor.

Keywords: Nociceptin/orphanin FQ, N/OFQ, nociceptin/orphanin FQ peptide (NOP) receptor, opioid receptor like-1 (ORL-1), opioid receptor-4 (OP4), kappa-type 3 opioid receptor (KOR-3), rat opioid receptor-C (ROR-C), obesity, food intake

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2008
Published on: 01 March, 2012
Page: [796 - 811]
Pages: 16
DOI: 10.2174/138955708784912139
Price: $65

Article Metrics

PDF: 10