Title: Antipsychotic Drugs and Cerebrovascular Events in Elderly Patients with Dementia: A Systematic Review
VOLUME: 8 ISSUE: 8
Author(s):Sara Mazzucco, Andrea Cipriani, Corrado Barbui and Salvatore Monaco
Affiliation:Department of Neurological Sciences and Vision, Section of Clinical Neurology, University of Verona, Piazzale L.A. Scuro, 10, 37134 Verona, Italy.
Keywords:Neuroleptics, typical antipsychotics, atypical antipsychotics, dopamine, dementia, cerebrovascular events
Abstract: Recently, Canadian, US and European health regulatory agencies issued warnings about an increased risk of stroke and death in elderly patients with dementia receiving atypical antipsychotics. Assessing both randomised and nonrandomised evidence, this systematic review found conflicting findings, particularly for risperidone. More research is needed to better inform clinical practice.